A Ubiquitin - like Enigma
نویسندگان
چکیده
1. Abstract 2. Introduction 2.1. Interferons 2.2. Ubiquitin-like modifiers 3. Discovery and history of ISG15 4. ISG15 sequence homology 5. Extracellular ISG15 6. Regulation of ISG15 expression 7. ISG15 conjugation, deconjugation, and modification enzymes 7.1. ISG15 activating enzyme UBE1L 7.2. ISG15 conjugating enzyme UBC8 7.3. Putative ISG15 E3 ligases 7.4. ISG15 protease UBP43 7.5. ISG15 processing enzymes 8. Targets of ISG15 modification 9. Possible roles of ISG15 and protein modification by ISG15 9.1. Possible role as a cytokine 9.2. Possible role in regulation of interferon signaling 9.3. Possible role in innate immunity and viral infections 9.4. Possible role in pregnancy 9.5. Possible role in cancer 9.6. Possible role in protein turnover 10. Perspectives 11. Acknowledgments 12. References
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